Leo J Bolles Clinic, IV Chelation Therapy, Homeopathic Remedies, Naturopathy, Acupuncture, Nutrition and Allergy, Nutritional, Biochemical, Vitamin, Mineral, deficiencies, imbalances, heavy metal detox, detoxification The Leo J. Bolles Clinic

15611 Bel-Red Rd., Bellevue WA, 98008 (425)881-2224

A PREVENTIVE MEDICINE CENTER

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    Nutritional, Biochemical, Vitamin and Mineral deficiencies or imbalances can be a major factor in the prevention, control and cure of disease.
    The philosophy of the physicians at the center is to balance the body chemistry, obtain maximum organ function and improve the body's own immune system.
    The Bolles Clinic is a management company that provides management services for Independent contractor physicians and other practitioners.
    Each practitioner acts of his or her own authority and provides part or all of the services listed.
    All medical services are offered only by a licensed medical professional.
     

    Summary# 35993

    Keywords:

    AGING, COGNITIVE FUNCTION - Vitamin B12, MMSE, CAMCOG, Methylmalonic Acid, MMA

    Topic:

    Inverse Association between Serum Methylmalonic Acid Levels and Cognitive Function in the Elderly

    Reference:

    "Methylmalonic acid and cognitive function in the Medical Research Council Cognitive Function and Ageing Study," McCracken C, Hudson P, et al, Am J Clin Nutr, 2006; 84(6): 1406-11. (Address: University Department of Psychiatry, Royal Liverpool University Hospital, Liverpool, United Kingdom).

    Summary:

    In a cross-sectional study involving 84 nondemented participants (over 69 years of age) from the Welsh cohort of the Medical Research Council's Cognitive Function and Aging Study, likely metabolically significant vitamin B12 deficiency - indicated by elevated serum levels of methylmalonic acid (MMA; a related metabolic marker of vitamin B12 deficiency) - was associated with lower cognitive scores of language comprehension and expression. Additionally, a high prevalence of likely metabolically significant vitamin B12 deficiency was observed in the elderly participants. Cognitive status was assessed by the Mini-Mental State Examination (MMSE) and the Cognitive Section of the Cambridge Mental Disorders of the Elderly Examination (CAMCOG). Likely metabolically significant vitamin B12 deficiency was observed in 43% of the participants. After adjusting for age and education, higher MMA levels were associated with lower MMSE scores. Additionally, an inverse association was foun d between serum MMA levels with CAMCOG scores of ideational praxis, language comprehension, and language expression. Furthermore, a weak but significant correlation was observed between serum folate with language, remote memory, and constructional and ideational praxis scores. Thus, the authors of this study conclude, "The high prevalence of likely metabolically significant vitamin B-12 deficiency in the elderly is associated with lower cognitive function scores and particularly with lower scores of language comprehension and expression."

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