The Leo J. Bolles Clinic 15611 Bel-Red Rd., Bellevue WA, 98008 (425)881-2224 A PREVENTIVE MEDICINE CENTER

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Nutritional, Biochemical, Vitamin and Mineral deficiencies or imbalances can be a major factor in the prevention, control and cure of disease.
The philosophy of the physicians at the center is to balance the body chemistry, obtain maximum organ function and improve the body's own immune system.
The Bolles Clinic is a management company that provides management services for Independent contractor physicians and other practitioners.
Each practitioner acts of his or her own authority and provides part or all of the services listed.
All medical services are offered only by a licensed medical professional.

Summary# 44875 Keywords: ENDOTHELIAL FUNCTION, CORONARY ARTERY DISEASE - Folic Acid, Homocysteine Topic: High-Dose Folic Acid Improves Endothelial Function in Coronary Artery Disease, Independent of Its Homocysteine Lowering Effect Reference: "High- but not low-dose folic acid improves endothelial function in coronary artery disease," Moat SJ, Madhavan A, et al, Eur J Clin Invest, 2006; 36(12): 850-9. (Address: Department of Medical Biochemistry, University Hospital of Wales, Cardiff, UK). Summary: In a study involving 128 patients with coronary artery disease (CAD), supplementation with high-dose folic acid (5 mg/d) was found to significantly improve endothelial function, independent of its effect on lowering plasma Hcy levels. The study involved several separate studies. In one study - the folic acid study - subjects (n=84) were divided into 3 groups. One group received 400 microg/d folic acid, a second group received 5 mg/d folic acid, and the third group received a placebo. In a second study - the betaine study - subjects (n=44) were divided into 2 groups, in which one group received 3 g b.i.d. betaine and the other group received placebo. All treatments were given for a period of 6 weeks. In the third study - an in vitro study - the effect of folic acid on endothelial function and endothelial nitric oxide synthase (eNOS) dimerization in isolated rabbit aortic rings and cultured porcine aortic endothelial cells (PAEC) was investigated. Results found that subj ects who received supplementation with folate at either 400 microg/d or 5 mg/d had significant increases in plasma folate and significant decreases in plasma Hcy, while only subjects who received 5 mg/d had significant improvements in flow-mediated dilation - a change which was independent of the reduction in Hcy. In the subgroup of subjects who received betaine, a significant impairment in flow-mediated dilation was found, despite a reduction in plasma Hcy. Results of the in vitro studies found that folic acid reversed endothelial dysfunction and promoted eNOS dimerization in PAEC. These results suggest that supplementation with high-dose folic acid, which has been shown to improve endothelial function independent of its effect on plasma Hcy levels, may be of benefit to patients with CAD. Click here for products related to this article This article provided by Vitasearch   Email Us! any questions on services on products. Go Back